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Blue Sapphire vs Demonic Rune

Blue Sapphire
Sells for 70 Silver to vendors
Item Level 55

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Demonic Rune
Binds when picked up
Use: Restores 900 to 1500 mana at the cost of 600 to 1000 life.
Sells for 6 Silver to vendors
Item Level 50

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Side by side:

Set your class weights in Preferences to see which is better for you.

Stat Blue Sapphire Demonic Rune Δ
Item Level 55 50 −5
Sell Price 70s 6s −64s
Binding Binds when picked up

Δ is Demonic Rune minus Blue Sapphire: green where Demonic Rune is better, red where it is worse (a lower required level is better; speed and sell price have no better side). Total Stats adds up Str, Agi, Sta, Int and Spi.

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