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Orb of Fire vs Alchemist's Stone

Orb of Fire
Binds when picked up
Trinket
Sells for 39 Silver 87 Copper to vendors
Item Level 46
Alchemist's Stone
Binds when picked up
Trinket
+4 Spirit
Requires Level 45
"Can be used for transmutations in place of a Philosopher's Stone."
Sells for 2 Gold 50 Silver to vendors
Item Level 50
CHANGED Changed in Forever: name, quality, item level, required level, type, stats.

Side by side:

Set your class weights in Preferences to see which is better for you.

Stat Orb of Fire Alchemist's Stone Δ
Item Level 46 50 +4
Required Level 45 +44
Spi +4 +4
Total Stats 4 +4
Sell Price 39s 87c 2g 50s +2g 10s 13c
Binding Binds when picked up Binds when picked up

Δ is Alchemist's Stone minus Orb of Fire: green where Alchemist's Stone is better, red where it is worse (a lower required level is better; speed and sell price have no better side). Total Stats adds up Str, Agi, Sta, Int and Spi.

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