Combat Mana Potion vs Rune of the Gladiator

Combat Mana Potion
Binds when picked up
Requires Level 41
Use: Restores 900 to 1500 mana.
Sells for 2 Silver 75 Copper to vendors
Item Level 51

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Rune of the Gladiator
Binds when picked up
Classes: Warrior
Use: Engrave your boots with the Gladiator Stance rune: An aggressive stance that increases damage while you are wearing a shield by 10% and increases block chance by 10%, but reduces armor by 30% and threat generated by 30%. In addition, you gain 50% increased Rage when your auto-attack damages an enemy not targeting you. While wearing a shield in Gladiator Stance, you may use all abilities that are restricted to other stances.
Use: Learning
"Teaches you a new Engraving ability."
Item Level 50

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Side by side:

Set your class weights in Preferences to see which is better for you.

Stat Combat Mana Potion Rune of the Gladiator Δ
Item Level 51 50 −1
Required Level 41 −40
Sell Price 2s 75c −2s 75c
Binding Binds when picked up Binds when picked up

Δ is Rune of the Gladiator minus Combat Mana Potion: green where Rune of the Gladiator is better, red where it is worse (a lower required level is better; speed and sell price have no better side). Total Stats adds up Str, Agi, Sta, Int and Spi.

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