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Instant Toxin vs Rune of Portals

Instant Toxin
Classes: Rogue
Requires Level 24
Use: Coats a sword or dagger with poison that lasts for 30 minutes. Each strike has a chance of poisoning the enemy which instantly inflicts 10-30 damage.
Sells for 1 Silver to vendors
Item Level 24

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Rune of Portals
Sells for 5 Silver to vendors
Item Level 40

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Side by side:

Set your class weights in Preferences to see which is better for you.

Stat Instant Toxin Rune of Portals Δ
Item Level 24 40 +16
Required Level 24 −23
Sell Price 1s 5s +4s

Δ is Rune of Portals minus Instant Toxin: green where Rune of Portals is better, red where it is worse (a lower required level is better; speed and sell price have no better side). Total Stats adds up Str, Agi, Sta, Int and Spi.

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