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Eternium Lockbox vs Syncretist's Sigil

Eternium Lockbox
Sells for 5 Silver to vendors
Item Level 60

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Syncretist's Sigil
Binds when picked up
Classes: Paladin
Requires Level 60
Use: Permanently adds 10 Stamina, 7 Defense, and increases healing by up to 24 to a leg or head slot item. Does not stack with other enchantments for the selected equipment slot.
Item Level 60

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Side by side:

Set your class weights in Preferences to see which is better for you.

Stat Eternium Lockbox Syncretist's Sigil Δ
Item Level 60 60 0
Required Level 60 +59
Sell Price 5s −5s
Binding Binds when picked up

Δ is Syncretist's Sigil minus Eternium Lockbox: green where Syncretist's Sigil is better, red where it is worse (a lower required level is better; speed and sell price have no better side). Total Stats adds up Str, Agi, Sta, Int and Spi.

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