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Anti-Venom vs Aquadynamic Fish Lens

Anti-Venom
Use: Target is cured of poisons up to level 25.
Sells for 28 Copper to vendors
Item Level 16

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Aquadynamic Fish Lens
Use: When applied to your fishing pole, increases Fishing by 50 for 10 minutes.
Sells for 25 Copper to vendors
Item Level 20

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Side by side:

Set your class weights in Preferences to see which is better for you.

Stat Anti-Venom Aquadynamic Fish Lens Δ
Item Level 16 20 +4
Sell Price 28c 25c −3c

Δ is Aquadynamic Fish Lens minus Anti-Venom: green where Aquadynamic Fish Lens is better, red where it is worse (a lower required level is better; speed and sell price have no better side). Total Stats adds up Str, Agi, Sta, Int and Spi.

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