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Instant Poison vs Lesser Healthstone

Instant Poison
Classes: Rogue
Requires Level 20
Use: Coats a weapon with poison that lasts for 30 minutes. Each strike has a 20% chance of poisoning the enemy which instantly inflicts 13 to 17 Nature damage. 60 charges.
Sells for 5 Copper to vendors
Item Level 20

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Lesser Healthstone
Requires Level 12
Use: Instantly restores 275 life.
Item Level 22

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Side by side:

Set your class weights in Preferences to see which is better for you.

Stat Instant Poison Lesser Healthstone Δ
Item Level 20 22 +2
Required Level 20 12 −8
Sell Price 5c −5c

Δ is Lesser Healthstone minus Instant Poison: green where Lesser Healthstone is better, red where it is worse (a lower required level is better; speed and sell price have no better side). Total Stats adds up Str, Agi, Sta, Int and Spi.

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